YT blood group antigen

Common Name(s)

YT blood group antigen

The antibody defining the very common antigen Yt(a) was the cause of a cross-matching difficulty investigated by {3:Eaton et al. (1956)}. It was presumed to be the result of previous transfusions. Among 1,051 English people, 4 negatives were found. Positives showed 2 grades of strength of reaction; on the assumption that the weaker reactors represented heterozygotes, an estimate of gene frequency simply by counting was possible. {8:Telen et al. (1990)} found that the Yt (Cartwright) red cell antigen resided on an unidentified phosphatidylinositol (PI)-linked protein. {9:Telen and Whitsett (1992)} identified a patient with the hitherto unreported Yt(a-b-) phenotype in whom studies allowed localization of the Yt antigens to the acetylcholinesterase molecule. {9:Telen and Whitsett (1992)} found that binding of antibodies to several membrane proteins including CD55 ({125240}), CD58 ({153420}), and CD59 ({107271}) were normal, whereas 4 monoclonal antibodies to different acetylcholinesterase epitopes reacted only weakly with Yt(a-b-) erythrocytes. In addition, enzymatic assay of acetylcholinesterase activity of Yt(a-b-) erythrocytes demonstrated only 15% of the normal amount of enzyme activity. The use of anti-Yt(a) in radioimmunoprecipitation experiments demonstrated the expected 160 kD of the acetylcholinesterase molecule from normal erythrocyte membrane proteins, but not from Yt(a-b-) erythrocytes. {7:Spring et al. (1992)} obtained similar results. Thus, acetylcholinesterase is the PI-linked protein that represents the Yt antigen.
 

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Condition Specific Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "YT blood group antigen" returned 1 free, full-text research articles on human participants. First 3 results:

Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype.
 

Author(s): N Rao, C F Whitsett, S M Oxendine, M J Telen

Journal: Blood. 1993 Feb;81(3):815-9.

 

The Cartwright (Yt) blood group antigens have previously been shown likely to reside on a phosphatidylinositol-linked erythrocyte membrane protein. In this study, an unusual individual whose red blood cells (RBCs) were of the previously unreported Yt(a-b-) phenotype were used, along ...

Last Updated: 31 Dec 1969

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