Cleft lip and/or palate malrotation cardiopathy, also known as McPherson-Clemens syndrome, is a rare combination of birth defects, or a syndrome. Cleft lip and/or palate, a feature of this syndrome, is the incomplete formation of the lip and mouth, creating a gap in the upper lip as well as a small hole in the roof of the mouth. Other facial abnormalities include widely spaced eyes and generally flattened-appearing facial structure. Malrotation refers to abnormal formation of the gastrointestinal tract, or gut, which may require surgery later in life. McPherson-Clemens syndrome may also include heart defects, or cardiopathies. Research regarding the condition is currently very limited.