Cloacal exstrophy is a rare genetic condition. This condition results from a mutation or error in a person’s DNA or genes that causes severe birth defects where much of the abdominal organs, like the bladder and intestines, are exposed. It can also cause the male and female genitalia, the penis or clitoris respectively, to split, and the anus can be sealed. Cloacal exstrophy occurs 1 in 400,000 live births and can usually be diagnosed before birth during an ultrasound. Although there is currently no cure for cloacal exstrophy, there are various resources available to patients to help manage the condition and treat birth defects, including surgical repair, which may also require several additional reconstructive surgeries over many years. Doctors seek help from various therapists and community services to provide support and care for families affected by cloacal exstrophy.