Coloboma with Microphthalmia refers to a rare eye disorder that is characterized by a defect in the visual system and abnormally small eyeballs. Defects occur anywhere in the visual system, including the eyes, retina, optic tract and the optic nerve. Hence, individuals with this disorder have severe vision problems. The severity of the disorder depends on the size of the defect in the visual system. Abnormally small eyeballs will cause vision to be further impaired. Vision problems can affect an individual significantly, inhibiting their ability to perform day-to-day tasks. The condition is often diagnosed during childhood, since individuals are born with the condition. Eye specialists often diagnose this condition after detecting a defect in the visual system and observing small eyeballs from eye examinations or brain scans. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Eye and brain specialists may suggest patients undergo surgery to repair the vision defect.