Tylosis is a rare genetic disorder. The most common feature of tylosis is thickening of the outside layer of the skin (hyperkeratosis). Sometimes, tylosis is the result of an atypical amount of the protein keratin in the skin. This difference in skin happens on the palms of the hands and the soles of the feet. Tylosis can either be only on the areas that are the most used or all over the palms and soles. Patterns can be different between the hands and feet. Individuals may also have white patches, called buccal mucosa leukoplakia, in their mouth on the inner cheeks.
There are two types of tylosis. “Type A tylosis” shows symptoms later in life. It develops between the ages of 5 and 15. It most commonly develops around ages 6 to 7. Type A tylosis is related to getting esophageal cancer. Esophageal cancer is a disease of the tube-like organ that carries food from the mouth to the stomach. “Type B tylosis” is seen within the first year of life. So far, type B tylosis has not been related to cancer like type A has. It is important to know which type of tylosis an individual has so that he or she can have the right treatment and know what to expect in the future.
Tylosis is passed down from parent to child in an autosomal dominant manner. This means that a person inherits one changed, or mutated, copy of a gene in order to have the condition. Someone with tylosis has a 50/50 chance of passing it on to their children. If you or a family member has been diagnosed with tylosis, talk with your doctor about the most current treatment options. Support groups are also good resources of support and information.
Description Last Updated: Feb 12, 2018